Industry 5.0 represents an important step change in industrial policy thinking by the European Commission. Current political, economic, ecological and social developments and concerns have created an opportune time for Industry 5.0. It requires governments, the social partners and other stakeholders to focus on human-centricity, sustainability and resilience. However, at the moment, Industry 5.0 is still a policy concept in need of clarification and support. Although positioned by DGR&I as an extension of Industry 4.0, it clearly has different practical concerns. It can however draw lessons from Industry 4.0 if it is to be translated from policy into practice.